ABSTRACT
Objective :To explore influence of dual-and triple-anticoagulant therapy on hemorrhage events ,laboratory in-dexes and cardiovascular events after percutaneous coronary intervention (PCI) in patients with atrial fibrillation (AF) complicated coronary heart disease (CHD).Methods : Clinical data of 100 AF + CHD patients were analyzed .All subjects received PCI and anticoagulant therapy after PCI .Dual-therapy group (n＝ 50) received dual-anticoagulant program and triple-therapy group (n＝50) received triple-anticoagulant program.Levels of blood C reactive protein (CRP) ,fibrinogen (Fg) ,D-dimer (D-D) and platelet count (PLT) before and after treatment ,incidence of hemorrhage events and adverse cardiovascular events during treatment were compared between two groups .Results : Compared with dual-therapy group af-ter 12-month treatment ,there were significant reductions in blood levels of CRP [(16-81 ± 4-49) mg／L vs.(7-86 ± 1-64) mg／L] ,PLT [ (298-47 ± 54-33)×109／L vs.(148-89 ± 23-11)×109／L] ,Fg [ (5-59 ± 1-41) g／L vs.(2-14 ± 0-56) g／L] and D-D [(0-37 ± 0-08) mg／L vs.(0-21 ± 0-06) mg／L] in triple-therapy group ,P＝0-001 all.Incidence rate of ad-verse cardiovascular events in triple-therapy group was significantly lower than that of dual-therapy group (6-00% vs. 22-00%, P＝0-021) ,there was no significant in incidence rate of hemorrhage events between two groups , P＝0-182-Conclusion : Triple-anticoagulant therapy can significantly improve therapeutic effect with high safety in AF + CHD pa-tients after PCI ,which is worth extending .